An introduction to the issue of the ebola hemorrhagic fever

EHRs as a public health tool at the point of care. Further research is being done to help prevent future outbreaks. Footnotes Conflict of Interest: Five strains of Ebola virus, which are genetically and antigenetically distinct, have been identified over the years.

This brief history of Marburg virus presages the very similar course of events with Ebola virus. This deadly virus can result in a deadly acute febrile hemorrhagic illness. New Diagnostic Tool for Ebola Infection The diagnosis of Ebola virus infection is an actual challenge since the early detection means the success in disease management and control.

Was the virus causing sporadic human infections that remained undetected because the patients never contaminated hospitals to produce the savage nosocomial epidemics that brought Ebola virus to medical attention? The total case tally is probably underestimated owing to inaccessibility of some of villages in the affected areas and reluctance to co-operate on the part of the local communities.

In contrast, patients in the affected villages were segregated through traditional methods of quarantine, a step that controlled the situation outside the clinics. Import into RefWorks 1. Secondary symptoms includes haemorrhaging i.

Post-exposure efficacy of oral T Favipiravir against inhalational Ebola virus infection in a mouse model. Medical facilities had been closed because of the high death toll among the staff, thus eliminating major centers for dissemination of infection through the use of unsterilized needles and syringes and the lack of barrier-nursing techniques.

Ebola Virus and Disease

Epidemiologic studies that were conducted in connection with both epidemics [ 1920 ] successfully traced the virus introductions to one Philippine exporter but failed to detect the actual source of the virus.

Clinical disease The clinical syndrome seen among patients in Kikwit resembled that seen in [ 1311 ], but bleeding was less common and other significant findings were identified, as reported by Bwaka et al.

In addition, virologic analysis of the incomplete specimen set that was available did not lend support for efficacy. These include the Tai Forest, Reston, Sudan, Zaire and Bundibudyo viruses Bundibudyo virus was identified for the first time during an outbreak in Uganda in Attempts to work in the remote areas where the monkeys were captured have been too dangerous due to political instability.

In the Ebola outbreak in Kikwit, late transmission of disease was not detected in follow-up of contacts of several survivors [ 44 ].

Ebola Virus Infection: What Should Be Known?

At that time, commercial laboratory workers with a severe and unusual disease were admitted to a hospital in Marburg, Germany. During —, no less than five independent active sites of Ebola virus transmission were identified: To date, a total of cases from Guinea, from Sierra Leone and from Liberia and 14 from Nigeria have been recorded [ 3 ].

The monkeys, some of which had been shipped to Frankfurt, Germany, and Belgrade, Yugoslavia, were euthanatized, and the epidemic was contained with only 31 human cases and one generation of secondary transmission to health care workers and family members. Since Ebola may occur within three weeks of exposure, anyone with possible exposure might undergo an incubation period of the same timeframe.

Laboratory testing in this setting must also provide a differential diagnosis for Lassa fever, a hemorrhagic fever endemic to and commonly reported from the affected areas, among other likely causes of disease that may present with similar clinical features.

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Large donations flowed into WHO and directly to the DRC; however, there were difficulties with the disbursement of relief supplies and resources, acquisition of appropriate types of materials, and triage of the contributions. The widespread bleeding that occurs in affected people causes swelling and shock due to loss of blood volume.

Quarantine procedures were put in place in many countries to prevent the recurrence of disease introduced by imported monkeys [ 5 ], and tests were instituted to exclude Marburg virus from vaccine substrates [ 6 ].

General introduction into the Ebola virus biology and disease.

Community perceptions, fears and reluctance to co-operate can be especially problematic, and communication barriers must be bridged by well-designed and understandable health messages. US signs contract with ZMapp maker to accelerate development of the Ebola drug.

EHD is caused by the Ebola virus, a filovirus that is thought to be harbored by specific arboreal bat species in the affected regions [ 2 ].

What is Ebola Virus Disease?

It was possible, however, to make observations on eye complications [ 42 ], pregnancy [ 43 ], late sequelae [ 44 ], and an unusual case with mucormycosis complicating Ebola [ 45 ].Ebola Hemorrhagic Fever in Sudan The epicenter of this small outbreak of 17 cases and 7 deaths (CFR %) was the town of Yambio, near to the two previous Ebola sites (Nzara and Maridi).

22 During the Ebola outbreak, Kaluamba was affected again, with 37 cases and 16 deaths (CFR %). Johnson et al. [1] isolated and identified Ebola (EBO) virusas from human cases during a epidemic of hemorrhagic fever (HF) in the Democratic Republic of the Congo (DRC).

During the same year, EBO virus was isolated from patients during an HF epidemic in Sudan [ 2 ]. The spring of has brought a new calamity, the exotic infectious disease: Ebola Hemorrhagic Fever, which is caused by the highly contagious and pathogenic virus, transmitted directly by interpersonal contact or indirectly by.

The Ebola virus belongs to the viral family Filoviridae. Scientists also call it Filovirus. These virus types cause hemorrhagic fever or profuse bleeding inside and outside the body.

Ebola, caused by a filovirus, is a severe hemorrhagic fever with high mortality and without specific therapy. Goat, equine, and murine hyperimmune sera and monoclonal antibodies were protective in preexposure and postexposure trials in guinea pigs and mice.

Ebola Virus and Disease

– Goat hyperimmune sera was given to four adults following Ebola laboratory accidents ; in the definitely exposed patient, a mild. Ebola Virus Disease (EVD) is a rare and deadly disease in people and nonhuman primates. The viruses that cause EVD are located mainly in sub-Saharan Africa.

People can get EVD through direct contact with an infected animal (bat or nonhuman primate) or a sick or dead person infected with Ebola virus.

An introduction to the issue of the ebola hemorrhagic fever
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